==================================================================================================== 23andMe GENOME ANALYSIS REPORT Subject: Bill Syrros (Vasilios Syrros) Date: 2026-04-02 ==================================================================================================== SUMMARY STATISTICS ---------------------------------------------------------------------------------------------------- Total SNPs analyzed: 601,782 No-call rate: 1.18% Health-relevant SNPs found: 57 APOE STATUS (Critical for Alzheimer's Disease Risk) ---------------------------------------------------------------------------------------------------- APOE Genotype: ε3ε3 rs429358: TT rs7412: CC Interpretation: Common genotype, average AD risk, average cardiovascular risk ==================================================================================================== CARDIOVASCULAR ==================================================================================================== SNP: rs1801133 Gene: MTHFR (C677T) Location: Chromosome 1:11856378 Affects: Folate metabolism, homocysteine levels Your Genotype: AG Risk Allele: T Clinical Significance: MODERATE Meaning: Heterozygous genotype Notes: Elevated homocysteine increases cardiovascular and thrombotic risk ---------------------------------------------------------------------------------------------------- SNP: rs1801131 Gene: MTHFR (A1298C) Location: Chromosome 1:11854476 Affects: Folate metabolism (secondary site) Your Genotype: TT Risk Allele: C Clinical Significance: LOW Meaning: Homozygous TT genotype Notes: Less severe than C677T variant ---------------------------------------------------------------------------------------------------- SNP: rs6025 Gene: F5 (Factor V) (Leiden (R506Q)) Location: Chromosome 1:169519049 Affects: Blood clotting resistance to anticoagulant protein C Your Genotype: CC Risk Allele: A Clinical Significance: HIGH Meaning: Homozygous CC genotype Notes: Factor V Leiden - most common inherited thrombophilia in Europeans ---------------------------------------------------------------------------------------------------- SNP: rs429358 Gene: APOE (ε2/ε3/ε4 (Cys112Arg)) Location: Chromosome 19:45411941 Affects: Cholesterol metabolism, Alzheimer's disease risk Your Genotype: TT Risk Allele: C (ε4) Clinical Significance: HIGH Meaning: ε2/ε2 genotype (APOE2) - lowest Alzheimer's risk, lower LDL Notes: Requires rs7412 to determine full APOE status ---------------------------------------------------------------------------------------------------- SNP: rs7412 Gene: APOE (ε2/ε3/ε4 (Arg158Cys)) Location: Chromosome 19:45412079 Affects: Cholesterol metabolism, Alzheimer's disease risk Your Genotype: CC Risk Allele: T (ε2) Clinical Significance: HIGH Meaning: ε3 or ε4 allele Notes: Combined with rs429358 to determine APOE2/3/4 status ---------------------------------------------------------------------------------------------------- SNP: rs662 Gene: PON1 (Q192R) Location: Chromosome 7:94937446 Affects: Oxidative stress protection, HDL function Your Genotype: CT Risk Allele: A Clinical Significance: LOW Meaning: Heterozygous genotype Notes: Affects HDL's ability to protect against LDL oxidation ---------------------------------------------------------------------------------------------------- SNP: rs5186 Gene: AGTR1 (A1166C) Location: Chromosome 3:148459988 Affects: Blood pressure regulation Your Genotype: AC Risk Allele: C Clinical Significance: MODERATE Meaning: Intermediate risk Notes: Affects angiotensin II signaling in blood vessels ---------------------------------------------------------------------------------------------------- SNP: rs1800796 Gene: IL6 (-174G/C) Location: Chromosome 7:22766246 Affects: Inflammation, IL-6 levels Your Genotype: GG Risk Allele: C Clinical Significance: LOW Meaning: Higher IL-6 production, pro-inflammatory Notes: IL-6 is a key inflammatory cytokine ---------------------------------------------------------------------------------------------------- SNP: rs1800795 Gene: IL6 (-174G>C) Location: Chromosome 7:22766645 Affects: IL-6 levels and inflammation Your Genotype: GG Risk Allele: G Clinical Significance: LOW Meaning: Increased IL-6 levels Notes: May be same as rs1800796 ---------------------------------------------------------------------------------------------------- SNP: rs1800629 Gene: TNF (-308G/A) Location: Chromosome 6:31543031 Affects: TNF-alpha inflammation marker Your Genotype: AG Risk Allele: A Clinical Significance: LOW Meaning: Intermediate TNF-alpha levels Notes: TNF-alpha is a major inflammatory cytokine ---------------------------------------------------------------------------------------------------- SNP: rs3798220 Gene: LPA (IVS25+323C/G) Location: Chromosome 6:160961137 Affects: Lipoprotein(a) levels, cardiovascular risk Your Genotype: TT Risk Allele: G Clinical Significance: MODERATE Meaning: Homozygous TT genotype Notes: Elevated Lp(a) is independent cardiovascular risk factor ---------------------------------------------------------------------------------------------------- SNP: rs10455872 Gene: LPA (Pentanucleotide repeat) Location: Chromosome 6:161010118 Affects: Lipoprotein(a) levels, cardiovascular risk Your Genotype: AA Risk Allele: T Clinical Significance: MODERATE Meaning: Homozygous AA genotype Notes: Works with rs3798220 to determine Lp(a) phenotype ---------------------------------------------------------------------------------------------------- ==================================================================================================== DRUG METABOLISM ==================================================================================================== SNP: rs762551 Gene: CYP1A2 (C163A (-163)) Location: Chromosome 15:75041917 Affects: Caffeine metabolism speed Your Genotype: AA Risk Allele: A Clinical Significance: LOW Meaning: Slow caffeine metabolizer, jitteriness/anxiety at normal doses Notes: Explains individual caffeine sensitivity; affects 1-2 day half-life ---------------------------------------------------------------------------------------------------- SNP: rs1229984 Gene: ADH1B (Arg47His) Location: Chromosome 4:100239319 Affects: Alcohol metabolism speed Your Genotype: CC Risk Allele: A Clinical Significance: MODERATE Meaning: Homozygous CC genotype Notes: Asian populations enriched for fast metabolism; protective against alcoholism ---------------------------------------------------------------------------------------------------- SNP: rs671 Gene: ALDH2 (Glu504Lys) Location: Chromosome 12:112241766 Affects: Aldehyde dehydrogenase, alcohol flush reaction Your Genotype: GG Risk Allele: A Clinical Significance: MODERATE Meaning: Normal acetaldehyde metabolism Notes: East Asian variant; 50% of populations in China, Japan, Korea have deficiency ---------------------------------------------------------------------------------------------------- SNP: rs4149056 Gene: SLCO1B1 (T521C) Location: Chromosome 12:21331549 Affects: Statin metabolism, drug interactions Your Genotype: TT Risk Allele: C Clinical Significance: MODERATE Meaning: Normal statin metabolism Notes: Important for statin dosing and side effect risk ---------------------------------------------------------------------------------------------------- ==================================================================================================== FITNESS ==================================================================================================== SNP: rs1815739 Gene: ACTN3 (R577X) Location: Chromosome 11:66328095 Affects: Fast-twitch muscle fiber composition Your Genotype: CT Risk Allele: X Clinical Significance: MODERATE Meaning: R/X, intermediate phenotype Notes: ACTN3 R allele associated with elite sprinters; X/X with elite endurance athletes ---------------------------------------------------------------------------------------------------- SNP: rs8192678 Gene: PPARGC1A (Gly482Ser) Location: Chromosome 4:23815662 Affects: Aerobic capacity, mitochondrial biogenesis Your Genotype: CC Risk Allele: A Clinical Significance: MODERATE Meaning: Gly/Gly, superior aerobic capacity and mitochondrial function Notes: PGC-1alpha is master regulator of mitochondrial biogenesis ---------------------------------------------------------------------------------------------------- SNP: rs1800012 Gene: COL1A1 (Sp1 promoter (Xbal)) Location: Chromosome 17:48277749 Affects: Collagen synthesis, connective tissue strength Your Genotype: AC Risk Allele: S Clinical Significance: LOW Meaning: Heterozygous genotype Notes: Affects injury susceptibility in athletes ---------------------------------------------------------------------------------------------------- SNP: rs7136446 Gene: COL5A1 (rs7136446) Location: Chromosome 12:102838515 Affects: Collagen V synthesis, ligament/tendon properties Your Genotype: CT Risk Allele: C Clinical Significance: LOW Meaning: Heterozygous genotype Notes: Type V collagen affects soft tissue properties ---------------------------------------------------------------------------------------------------- ==================================================================================================== IMMUNE ==================================================================================================== SNP: rs2187668 Gene: HLA-DQ2.5 (rs2187668) Location: Chromosome 6:32605884 Affects: Celiac disease susceptibility Your Genotype: TT Risk Allele: A Clinical Significance: HIGH Meaning: Homozygous TT genotype Notes: 95% of celiac disease patients carry HLA-DQ2 or HLA-DQ8 ---------------------------------------------------------------------------------------------------- SNP: rs7454108 Gene: HLA-DQ8 (rs7454108) Location: Chromosome 6:32681483 Affects: Celiac disease susceptibility Your Genotype: TT Risk Allele: T Clinical Significance: HIGH Meaning: DQ8 homozygous, increased celiac risk Notes: Accounts for ~5% of celiac patients; complementary to DQ2 ---------------------------------------------------------------------------------------------------- ==================================================================================================== LONGEVITY ==================================================================================================== SNP: rs2802292 Gene: FOXO3 (rs2802292) Location: Chromosome 6:108908518 Affects: Longevity and healthy aging Your Genotype: GT Risk Allele: A Clinical Significance: MODERATE Meaning: Heterozygous genotype Notes: FOXO3 is major longevity gene; G allele associated with longer lifespan ---------------------------------------------------------------------------------------------------- SNP: rs1042522 Gene: TP53 (Arg72Pro) Location: Chromosome 17:7579472 Affects: Tumor suppression, cancer risk Your Genotype: CC Risk Allele: G Clinical Significance: MODERATE Meaning: Pro/Pro, potentially more efficient tumor suppression Notes: p53 is guardian of the genome; affects cancer risk ---------------------------------------------------------------------------------------------------- SNP: rs1800566 Gene: NQO1 (C609T (Pro187Ser)) Location: Chromosome 16:69745145 Affects: Antioxidant defense, NAD(P)H quinone oxidoreductase Your Genotype: GG Risk Allele: T Clinical Significance: MODERATE Meaning: Homozygous GG genotype Notes: Deficiency increases cancer risk from benzene and other quinones ---------------------------------------------------------------------------------------------------- SNP: rs4880 Gene: SOD2 (Ala16Val (Val9Ala)) Location: Chromosome 6:160113872 Affects: Mitochondrial antioxidant defense Your Genotype: AA Risk Allele: A (Val) Clinical Significance: MODERATE Meaning: Val/Val, reduced mitochondrial superoxide dismutase activity Notes: MnSOD is key mitochondrial antioxidant defense ---------------------------------------------------------------------------------------------------- ==================================================================================================== MENTAL/COGNITIVE ==================================================================================================== SNP: rs4680 Gene: COMT (Val158Met) Location: Chromosome 22:19951271 Affects: Catechol metabolism, dopamine/norepinephrine breakdown Your Genotype: AG Risk Allele: A (Met allele) Clinical Significance: MODERATE Meaning: Val/Met, intermediate metabolism Notes: Warrior vs Worrier phenotype; also affects pain sensitivity ---------------------------------------------------------------------------------------------------- SNP: rs6265 Gene: BDNF (Val66Met) Location: Chromosome 11:27679916 Affects: Brain-derived neurotrophic factor, neuroplasticity, learning Your Genotype: CC Risk Allele: A (Met) Clinical Significance: MODERATE Meaning: Homozygous CC genotype Notes: Met allele associated with anxiety-like traits and depression risk ---------------------------------------------------------------------------------------------------- SNP: rs53576 Gene: OXTR (rs53576) Location: Chromosome 3:8804371 Affects: Oxytocin receptor, social bonding, empathy Your Genotype: GG Risk Allele: A Clinical Significance: LOW Meaning: Lower oxytocin receptor expression, less empathy/social sensitivity Notes: Affects social bonding, parenting, and stress response ---------------------------------------------------------------------------------------------------- SNP: rs4570625 Gene: TPH2 (G/A (-703)) Location: Chromosome 12:72331923 Affects: Tryptophan hydroxylase, serotonin synthesis Your Genotype: GG Risk Allele: A Clinical Significance: LOW Meaning: Higher serotonin production Notes: Polymorphism affects serotonin availability ---------------------------------------------------------------------------------------------------- SNP: rs6311 Gene: HTR2A (-1438G/A) Location: Chromosome 13:47471478 Affects: Serotonin 2A receptor, mood, aggression Your Genotype: TT Risk Allele: A Clinical Significance: LOW Meaning: Homozygous TT genotype Notes: Associated with depression, suicidality, and aggression ---------------------------------------------------------------------------------------------------- SNP: rs1800497 Gene: DRD2/ANKK1 (Taq1A) Location: Chromosome 11:113270828 Affects: Dopamine receptor density, motivation, reward Your Genotype: GG Risk Allele: T (A1 allele) Clinical Significance: MODERATE Meaning: Homozygous GG genotype Notes: A1 allele associated with lower dopamine sensitivity and addiction ---------------------------------------------------------------------------------------------------- ==================================================================================================== METABOLIC ==================================================================================================== SNP: rs1801282 Gene: PPARG (Pro12Ala) Location: Chromosome 3:12393125 Affects: Insulin sensitivity, metabolic syndrome risk Your Genotype: CC Risk Allele: G Clinical Significance: MODERATE Meaning: Normal insulin sensitivity Notes: Ala allele is protective, reduces diabetes risk by ~25% ---------------------------------------------------------------------------------------------------- SNP: rs7903146 Gene: TCF7L2 (rs7903146) Location: Chromosome 10:114758349 Affects: Type 2 diabetes risk (strongest known locus) Your Genotype: CT Risk Allele: T Clinical Significance: HIGH Meaning: ~1.4x increased diabetes risk Notes: Most significant T2D susceptibility gene; each T allele ~20% increased risk ---------------------------------------------------------------------------------------------------- SNP: rs5219 Gene: KCNJ11 (E23K) Location: Chromosome 11:17409572 Affects: Insulin secretion and glucose control Your Genotype: CC Risk Allele: A Clinical Significance: MODERATE Meaning: K allele, normal insulin secretion Notes: Affects ATP-sensitive potassium channel in pancreatic beta cells ---------------------------------------------------------------------------------------------------- SNP: rs13266634 Gene: SLC30A8 (R325W) Location: Chromosome 8:118184783 Affects: Zinc transporter, insulin secretion Your Genotype: CT Risk Allele: A Clinical Significance: MODERATE Meaning: Heterozygous genotype Notes: Zinc transport critical for insulin secretion ---------------------------------------------------------------------------------------------------- SNP: rs4402960 Gene: IGF2BP2 (rs4402960) Location: Chromosome 3:185511687 Affects: Type 2 diabetes risk Your Genotype: GT Risk Allele: T Clinical Significance: LOW Meaning: Heterozygous genotype Notes: Involved in glucose metabolism ---------------------------------------------------------------------------------------------------- SNP: rs10811661 Gene: CDKN2A/B (rs10811661) Location: Chromosome 9:22134094 Affects: Type 2 diabetes and pancreatic cancer risk Your Genotype: CT Risk Allele: A Clinical Significance: MODERATE Meaning: Heterozygous genotype Notes: Cell cycle regulator ---------------------------------------------------------------------------------------------------- SNP: rs9939609 Gene: FTO (A/T) Location: Chromosome 16:53820527 Affects: Obesity risk, appetite regulation Your Genotype: AT Risk Allele: A Clinical Significance: MODERATE Meaning: Intermediate obesity risk (~1.3x) Notes: Most significant obesity-associated SNP; affects appetite circuits ---------------------------------------------------------------------------------------------------- SNP: rs17782313 Gene: MC4R (rs17782313) Location: Chromosome 18:57851097 Affects: Obesity risk, appetite/satiety Your Genotype: TT Risk Allele: C Clinical Significance: MODERATE Meaning: Homozygous TT genotype Notes: Melanocortin-4 receptor crucial for appetite control ---------------------------------------------------------------------------------------------------- SNP: rs1042713 Gene: ADRB2 (Arg16Gly) Location: Chromosome 5:148206440 Affects: Beta-2 adrenergic receptor, metabolic rate Your Genotype: AA Risk Allele: C Clinical Significance: LOW Meaning: Arg/Arg, higher metabolic rate and norepinephrine sensitivity Notes: Affects sympathetic nervous system response ---------------------------------------------------------------------------------------------------- SNP: rs1042714 Gene: ADRB2 (Gln27Glu) Location: Chromosome 5:148206473 Affects: Beta-2 adrenergic receptor, weight regulation Your Genotype: CC Risk Allele: G Clinical Significance: LOW Meaning: Homozygous CC genotype Notes: Works with rs1042713 for metabolic effects ---------------------------------------------------------------------------------------------------- SNP: rs4994 Gene: ADRB3 (Trp64Arg) Location: Chromosome 8:37823798 Affects: Beta-3 adrenergic receptor, metabolic efficiency Your Genotype: AA Risk Allele: C Clinical Significance: LOW Meaning: Homozygous AA genotype Notes: Involved in thermogenesis and fat mobilization ---------------------------------------------------------------------------------------------------- ==================================================================================================== NUTRIENT METABOLISM ==================================================================================================== SNP: rs4988235 Gene: MCM6/LCT (C/T (-13910)) Location: Chromosome 2:136608646 Affects: Lactose tolerance Your Genotype: GG Risk Allele: A (old nomenclature) Clinical Significance: MODERATE Meaning: Homozygous GG genotype Notes: Determines adult lactase persistence; common in Northern European ancestry ---------------------------------------------------------------------------------------------------- SNP: rs1801394 Gene: MTRR (A66G) Location: Chromosome 5:7870973 Affects: B12 metabolism, methionine cycle Your Genotype: AG Risk Allele: A Clinical Significance: LOW Meaning: Intermediate enzyme activity Notes: Related to homocysteine metabolism ---------------------------------------------------------------------------------------------------- SNP: rs1805087 Gene: MTR (A2756G) Location: Chromosome 1:237048500 Affects: B12 and methionine metabolism Your Genotype: AA Risk Allele: A Clinical Significance: LOW Meaning: Potential B12/methionine metabolism issues Notes: Cofactor required for methylation reactions ---------------------------------------------------------------------------------------------------- SNP: rs602662 Gene: FUT2 (A/G) Location: Chromosome 19:49206985 Affects: B12 absorption, gut microbiota Your Genotype: AA Risk Allele: A Clinical Significance: LOW Meaning: Non-secretor, reduced B12 absorption from food Notes: FUT2 secretor status affects B12 and micronutrient availability ---------------------------------------------------------------------------------------------------- SNP: rs7041 Gene: GC/VDBP (D432E) Location: Chromosome 4:72618334 Affects: Vitamin D binding protein, vitamin D status Your Genotype: CC Risk Allele: A Clinical Significance: MODERATE Meaning: Homozygous CC genotype Notes: Affects vitamin D distribution and bioavailability ---------------------------------------------------------------------------------------------------- SNP: rs4588 Gene: GC/VDBP (T436K) Location: Chromosome 4:72618323 Affects: Vitamin D binding protein Your Genotype: GG Risk Allele: T Clinical Significance: MODERATE Meaning: Isoform 1f or 2 Notes: Works with rs7041 to determine VDBP isoform ---------------------------------------------------------------------------------------------------- SNP: rs1800562 Gene: HFE (C282Y) Location: Chromosome 6:26093141 Affects: Iron overload risk (hemochromatosis) Your Genotype: GG Risk Allele: A Clinical Significance: HIGH Meaning: Homozygous GG genotype Notes: Most common genetic cause of hemochromatosis ---------------------------------------------------------------------------------------------------- SNP: rs1799945 Gene: HFE (H63D) Location: Chromosome 6:26091179 Affects: Iron overload risk (secondary) Your Genotype: CG Risk Allele: G Clinical Significance: LOW Meaning: Heterozygous carrier Notes: Secondary hemochromatosis mutation; rarely causes disease alone ---------------------------------------------------------------------------------------------------- SNP: rs855791 Gene: TMPRSS6 (A736V) Location: Chromosome 22:37462936 Affects: Iron levels and hepcidin regulation Your Genotype: GG Risk Allele: T Clinical Significance: LOW Meaning: Homozygous GG genotype Notes: Regulates iron absorption through hepcidin ---------------------------------------------------------------------------------------------------- SNP: rs234706 Gene: CBS (C699T) Location: Chromosome 21:44485350 Affects: Homocysteine and sulfur metabolism Your Genotype: AG Risk Allele: T Clinical Significance: LOW Meaning: Heterozygous genotype Notes: CBS is gateway to sulfur metabolism ---------------------------------------------------------------------------------------------------- SNP: rs1695 Gene: GSTP1 (A313G (Ile105Val)) Location: Chromosome 11:67352689 Affects: Detoxification, glutathione S-transferase activity Your Genotype: AA Risk Allele: G Clinical Significance: LOW Meaning: Normal detox capacity Notes: Phase II detox enzyme for environmental toxins ---------------------------------------------------------------------------------------------------- SNP: rs1048943 Gene: CYP1A1 (A2455G) Location: Chromosome 15:75012985 Affects: Phase I detoxification (CYP1A1 induction) Your Genotype: TT Risk Allele: G Clinical Significance: LOW Meaning: Homozygous TT genotype Notes: Affects polycyclic aromatic hydrocarbon metabolism ---------------------------------------------------------------------------------------------------- ==================================================================================================== SLEEP/CIRCADIAN ==================================================================================================== SNP: rs1801260 Gene: CLOCK (A3111T) Location: Chromosome 4:56301369 Affects: Circadian rhythm, sleep timing Your Genotype: AA Risk Allele: T Clinical Significance: LOW Meaning: Morning preference, earlier sleep/wake timing Notes: CLOCK is master circadian regulator; affects chronotype ---------------------------------------------------------------------------------------------------- SNP: rs73598374 Gene: ADA (rs73598374) Location: Chromosome 20:43280227 Affects: Deep sleep efficiency Your Genotype: CC Risk Allele: A Clinical Significance: LOW Meaning: Homozygous CC genotype Notes: Adenosine deaminase affects adenosine-mediated sleep pressure ----------------------------------------------------------------------------------------------------