{
  "metadata": {
    "total_snps": 601782,
    "no_call_rate": 1.1803277598864705,
    "chromosomal_distribution": {
      "1": 46659,
      "2": 46127,
      "3": 38516,
      "4": 33914,
      "5": 34385,
      "6": 40383,
      "7": 33051,
      "8": 30266,
      "9": 26586,
      "10": 29209,
      "11": 29321,
      "12": 28450,
      "13": 21652,
      "14": 18695,
      "15": 18281,
      "16": 19197,
      "17": 18710,
      "18": 16490,
      "19": 12963,
      "20": 14494,
      "21": 8461,
      "22": 9096,
      "X": 19478,
      "Y": 2302,
      "MT": 5096
    }
  },
  "snp_findings": [
    {
      "rsid": "rs1801133",
      "gene": "MTHFR",
      "variant": "C677T",
      "category": "Cardiovascular",
      "affects": "Folate metabolism, homocysteine levels",
      "user_genotype": "AG",
      "risk_allele": "T",
      "chromosome": "1",
      "position": "11856378",
      "interpretation": "Heterozygous genotype",
      "clinical_significance": "moderate",
      "notes": "Elevated homocysteine increases cardiovascular and thrombotic risk"
    },
    {
      "rsid": "rs1801131",
      "gene": "MTHFR",
      "variant": "A1298C",
      "category": "Cardiovascular",
      "affects": "Folate metabolism (secondary site)",
      "user_genotype": "TT",
      "risk_allele": "C",
      "chromosome": "1",
      "position": "11854476",
      "interpretation": "Homozygous TT genotype",
      "clinical_significance": "low",
      "notes": "Less severe than C677T variant"
    },
    {
      "rsid": "rs6025",
      "gene": "F5 (Factor V)",
      "variant": "Leiden (R506Q)",
      "category": "Cardiovascular",
      "affects": "Blood clotting resistance to anticoagulant protein C",
      "user_genotype": "CC",
      "risk_allele": "A",
      "chromosome": "1",
      "position": "169519049",
      "interpretation": "Homozygous CC genotype",
      "clinical_significance": "high",
      "notes": "Factor V Leiden - most common inherited thrombophilia in Europeans"
    },
    {
      "rsid": "rs429358",
      "gene": "APOE",
      "variant": "\u03b52/\u03b53/\u03b54 (Cys112Arg)",
      "category": "Cardiovascular",
      "affects": "Cholesterol metabolism, Alzheimer's disease risk",
      "user_genotype": "TT",
      "risk_allele": "C (\u03b54)",
      "chromosome": "19",
      "position": "45411941",
      "interpretation": "\u03b52/\u03b52 genotype (APOE2) - lowest Alzheimer's risk, lower LDL",
      "clinical_significance": "high",
      "notes": "Requires rs7412 to determine full APOE status"
    },
    {
      "rsid": "rs7412",
      "gene": "APOE",
      "variant": "\u03b52/\u03b53/\u03b54 (Arg158Cys)",
      "category": "Cardiovascular",
      "affects": "Cholesterol metabolism, Alzheimer's disease risk",
      "user_genotype": "CC",
      "risk_allele": "T (\u03b52)",
      "chromosome": "19",
      "position": "45412079",
      "interpretation": "\u03b53 or \u03b54 allele",
      "clinical_significance": "high",
      "notes": "Combined with rs429358 to determine APOE2/3/4 status"
    },
    {
      "rsid": "rs1801282",
      "gene": "PPARG",
      "variant": "Pro12Ala",
      "category": "Metabolic",
      "affects": "Insulin sensitivity, metabolic syndrome risk",
      "user_genotype": "CC",
      "risk_allele": "G",
      "chromosome": "3",
      "position": "12393125",
      "interpretation": "Normal insulin sensitivity",
      "clinical_significance": "moderate",
      "notes": "Ala allele is protective, reduces diabetes risk by ~25%"
    },
    {
      "rsid": "rs662",
      "gene": "PON1",
      "variant": "Q192R",
      "category": "Cardiovascular",
      "affects": "Oxidative stress protection, HDL function",
      "user_genotype": "CT",
      "risk_allele": "A",
      "chromosome": "7",
      "position": "94937446",
      "interpretation": "Heterozygous genotype",
      "clinical_significance": "low",
      "notes": "Affects HDL's ability to protect against LDL oxidation"
    },
    {
      "rsid": "rs5186",
      "gene": "AGTR1",
      "variant": "A1166C",
      "category": "Cardiovascular",
      "affects": "Blood pressure regulation",
      "user_genotype": "AC",
      "risk_allele": "C",
      "chromosome": "3",
      "position": "148459988",
      "interpretation": "Intermediate risk",
      "clinical_significance": "moderate",
      "notes": "Affects angiotensin II signaling in blood vessels"
    },
    {
      "rsid": "rs1800796",
      "gene": "IL6",
      "variant": "-174G/C",
      "category": "Cardiovascular",
      "affects": "Inflammation, IL-6 levels",
      "user_genotype": "GG",
      "risk_allele": "C",
      "chromosome": "7",
      "position": "22766246",
      "interpretation": "Higher IL-6 production, pro-inflammatory",
      "clinical_significance": "low",
      "notes": "IL-6 is a key inflammatory cytokine"
    },
    {
      "rsid": "rs1800795",
      "gene": "IL6",
      "variant": "-174G>C",
      "category": "Cardiovascular",
      "affects": "IL-6 levels and inflammation",
      "user_genotype": "GG",
      "risk_allele": "G",
      "chromosome": "7",
      "position": "22766645",
      "interpretation": "Increased IL-6 levels",
      "clinical_significance": "low",
      "notes": "May be same as rs1800796"
    },
    {
      "rsid": "rs1800629",
      "gene": "TNF",
      "variant": "-308G/A",
      "category": "Cardiovascular",
      "affects": "TNF-alpha inflammation marker",
      "user_genotype": "AG",
      "risk_allele": "A",
      "chromosome": "6",
      "position": "31543031",
      "interpretation": "Intermediate TNF-alpha levels",
      "clinical_significance": "low",
      "notes": "TNF-alpha is a major inflammatory cytokine"
    },
    {
      "rsid": "rs3798220",
      "gene": "LPA",
      "variant": "IVS25+323C/G",
      "category": "Cardiovascular",
      "affects": "Lipoprotein(a) levels, cardiovascular risk",
      "user_genotype": "TT",
      "risk_allele": "G",
      "chromosome": "6",
      "position": "160961137",
      "interpretation": "Homozygous TT genotype",
      "clinical_significance": "moderate",
      "notes": "Elevated Lp(a) is independent cardiovascular risk factor"
    },
    {
      "rsid": "rs10455872",
      "gene": "LPA",
      "variant": "Pentanucleotide repeat",
      "category": "Cardiovascular",
      "affects": "Lipoprotein(a) levels, cardiovascular risk",
      "user_genotype": "AA",
      "risk_allele": "T",
      "chromosome": "6",
      "position": "161010118",
      "interpretation": "Homozygous AA genotype",
      "clinical_significance": "moderate",
      "notes": "Works with rs3798220 to determine Lp(a) phenotype"
    },
    {
      "rsid": "rs7903146",
      "gene": "TCF7L2",
      "variant": "rs7903146",
      "category": "Metabolic",
      "affects": "Type 2 diabetes risk (strongest known locus)",
      "user_genotype": "CT",
      "risk_allele": "T",
      "chromosome": "10",
      "position": "114758349",
      "interpretation": "~1.4x increased diabetes risk",
      "clinical_significance": "high",
      "notes": "Most significant T2D susceptibility gene; each T allele ~20% increased risk"
    },
    {
      "rsid": "rs5219",
      "gene": "KCNJ11",
      "variant": "E23K",
      "category": "Metabolic",
      "affects": "Insulin secretion and glucose control",
      "user_genotype": "CC",
      "risk_allele": "A",
      "chromosome": "11",
      "position": "17409572",
      "interpretation": "K allele, normal insulin secretion",
      "clinical_significance": "moderate",
      "notes": "Affects ATP-sensitive potassium channel in pancreatic beta cells"
    },
    {
      "rsid": "rs13266634",
      "gene": "SLC30A8",
      "variant": "R325W",
      "category": "Metabolic",
      "affects": "Zinc transporter, insulin secretion",
      "user_genotype": "CT",
      "risk_allele": "A",
      "chromosome": "8",
      "position": "118184783",
      "interpretation": "Heterozygous genotype",
      "clinical_significance": "moderate",
      "notes": "Zinc transport critical for insulin secretion"
    },
    {
      "rsid": "rs4402960",
      "gene": "IGF2BP2",
      "variant": "rs4402960",
      "category": "Metabolic",
      "affects": "Type 2 diabetes risk",
      "user_genotype": "GT",
      "risk_allele": "T",
      "chromosome": "3",
      "position": "185511687",
      "interpretation": "Heterozygous genotype",
      "clinical_significance": "low",
      "notes": "Involved in glucose metabolism"
    },
    {
      "rsid": "rs10811661",
      "gene": "CDKN2A/B",
      "variant": "rs10811661",
      "category": "Metabolic",
      "affects": "Type 2 diabetes and pancreatic cancer risk",
      "user_genotype": "CT",
      "risk_allele": "A",
      "chromosome": "9",
      "position": "22134094",
      "interpretation": "Heterozygous genotype",
      "clinical_significance": "moderate",
      "notes": "Cell cycle regulator"
    },
    {
      "rsid": "rs9939609",
      "gene": "FTO",
      "variant": "A/T",
      "category": "Metabolic",
      "affects": "Obesity risk, appetite regulation",
      "user_genotype": "AT",
      "risk_allele": "A",
      "chromosome": "16",
      "position": "53820527",
      "interpretation": "Intermediate obesity risk (~1.3x)",
      "clinical_significance": "moderate",
      "notes": "Most significant obesity-associated SNP; affects appetite circuits"
    },
    {
      "rsid": "rs17782313",
      "gene": "MC4R",
      "variant": "rs17782313",
      "category": "Metabolic",
      "affects": "Obesity risk, appetite/satiety",
      "user_genotype": "TT",
      "risk_allele": "C",
      "chromosome": "18",
      "position": "57851097",
      "interpretation": "Homozygous TT genotype",
      "clinical_significance": "moderate",
      "notes": "Melanocortin-4 receptor crucial for appetite control"
    },
    {
      "rsid": "rs1042713",
      "gene": "ADRB2",
      "variant": "Arg16Gly",
      "category": "Metabolic",
      "affects": "Beta-2 adrenergic receptor, metabolic rate",
      "user_genotype": "AA",
      "risk_allele": "C",
      "chromosome": "5",
      "position": "148206440",
      "interpretation": "Arg/Arg, higher metabolic rate and norepinephrine sensitivity",
      "clinical_significance": "low",
      "notes": "Affects sympathetic nervous system response"
    },
    {
      "rsid": "rs1042714",
      "gene": "ADRB2",
      "variant": "Gln27Glu",
      "category": "Metabolic",
      "affects": "Beta-2 adrenergic receptor, weight regulation",
      "user_genotype": "CC",
      "risk_allele": "G",
      "chromosome": "5",
      "position": "148206473",
      "interpretation": "Homozygous CC genotype",
      "clinical_significance": "low",
      "notes": "Works with rs1042713 for metabolic effects"
    },
    {
      "rsid": "rs4994",
      "gene": "ADRB3",
      "variant": "Trp64Arg",
      "category": "Metabolic",
      "affects": "Beta-3 adrenergic receptor, metabolic efficiency",
      "user_genotype": "AA",
      "risk_allele": "C",
      "chromosome": "8",
      "position": "37823798",
      "interpretation": "Homozygous AA genotype",
      "clinical_significance": "low",
      "notes": "Involved in thermogenesis and fat mobilization"
    },
    {
      "rsid": "rs4988235",
      "gene": "MCM6/LCT",
      "variant": "C/T (-13910)",
      "category": "Nutrient Metabolism",
      "affects": "Lactose tolerance",
      "user_genotype": "GG",
      "risk_allele": "A (old nomenclature)",
      "chromosome": "2",
      "position": "136608646",
      "interpretation": "Homozygous GG genotype",
      "clinical_significance": "moderate",
      "notes": "Determines adult lactase persistence; common in Northern European ancestry"
    },
    {
      "rsid": "rs1801394",
      "gene": "MTRR",
      "variant": "A66G",
      "category": "Nutrient Metabolism",
      "affects": "B12 metabolism, methionine cycle",
      "user_genotype": "AG",
      "risk_allele": "A",
      "chromosome": "5",
      "position": "7870973",
      "interpretation": "Intermediate enzyme activity",
      "clinical_significance": "low",
      "notes": "Related to homocysteine metabolism"
    },
    {
      "rsid": "rs1805087",
      "gene": "MTR",
      "variant": "A2756G",
      "category": "Nutrient Metabolism",
      "affects": "B12 and methionine metabolism",
      "user_genotype": "AA",
      "risk_allele": "A",
      "chromosome": "1",
      "position": "237048500",
      "interpretation": "Potential B12/methionine metabolism issues",
      "clinical_significance": "low",
      "notes": "Cofactor required for methylation reactions"
    },
    {
      "rsid": "rs602662",
      "gene": "FUT2",
      "variant": "A/G",
      "category": "Nutrient Metabolism",
      "affects": "B12 absorption, gut microbiota",
      "user_genotype": "AA",
      "risk_allele": "A",
      "chromosome": "19",
      "position": "49206985",
      "interpretation": "Non-secretor, reduced B12 absorption from food",
      "clinical_significance": "low",
      "notes": "FUT2 secretor status affects B12 and micronutrient availability"
    },
    {
      "rsid": "rs7041",
      "gene": "GC/VDBP",
      "variant": "D432E",
      "category": "Nutrient Metabolism",
      "affects": "Vitamin D binding protein, vitamin D status",
      "user_genotype": "CC",
      "risk_allele": "A",
      "chromosome": "4",
      "position": "72618334",
      "interpretation": "Homozygous CC genotype",
      "clinical_significance": "moderate",
      "notes": "Affects vitamin D distribution and bioavailability"
    },
    {
      "rsid": "rs4588",
      "gene": "GC/VDBP",
      "variant": "T436K",
      "category": "Nutrient Metabolism",
      "affects": "Vitamin D binding protein",
      "user_genotype": "GG",
      "risk_allele": "T",
      "chromosome": "4",
      "position": "72618323",
      "interpretation": "Isoform 1f or 2",
      "clinical_significance": "moderate",
      "notes": "Works with rs7041 to determine VDBP isoform"
    },
    {
      "rsid": "rs1800562",
      "gene": "HFE",
      "variant": "C282Y",
      "category": "Nutrient Metabolism",
      "affects": "Iron overload risk (hemochromatosis)",
      "user_genotype": "GG",
      "risk_allele": "A",
      "chromosome": "6",
      "position": "26093141",
      "interpretation": "Homozygous GG genotype",
      "clinical_significance": "high",
      "notes": "Most common genetic cause of hemochromatosis"
    },
    {
      "rsid": "rs1799945",
      "gene": "HFE",
      "variant": "H63D",
      "category": "Nutrient Metabolism",
      "affects": "Iron overload risk (secondary)",
      "user_genotype": "CG",
      "risk_allele": "G",
      "chromosome": "6",
      "position": "26091179",
      "interpretation": "Heterozygous carrier",
      "clinical_significance": "low",
      "notes": "Secondary hemochromatosis mutation; rarely causes disease alone"
    },
    {
      "rsid": "rs855791",
      "gene": "TMPRSS6",
      "variant": "A736V",
      "category": "Nutrient Metabolism",
      "affects": "Iron levels and hepcidin regulation",
      "user_genotype": "GG",
      "risk_allele": "T",
      "chromosome": "22",
      "position": "37462936",
      "interpretation": "Homozygous GG genotype",
      "clinical_significance": "low",
      "notes": "Regulates iron absorption through hepcidin"
    },
    {
      "rsid": "rs234706",
      "gene": "CBS",
      "variant": "C699T",
      "category": "Nutrient Metabolism",
      "affects": "Homocysteine and sulfur metabolism",
      "user_genotype": "AG",
      "risk_allele": "T",
      "chromosome": "21",
      "position": "44485350",
      "interpretation": "Heterozygous genotype",
      "clinical_significance": "low",
      "notes": "CBS is gateway to sulfur metabolism"
    },
    {
      "rsid": "rs1695",
      "gene": "GSTP1",
      "variant": "A313G (Ile105Val)",
      "category": "Nutrient Metabolism",
      "affects": "Detoxification, glutathione S-transferase activity",
      "user_genotype": "AA",
      "risk_allele": "G",
      "chromosome": "11",
      "position": "67352689",
      "interpretation": "Normal detox capacity",
      "clinical_significance": "low",
      "notes": "Phase II detox enzyme for environmental toxins"
    },
    {
      "rsid": "rs1048943",
      "gene": "CYP1A1",
      "variant": "A2455G",
      "category": "Nutrient Metabolism",
      "affects": "Phase I detoxification (CYP1A1 induction)",
      "user_genotype": "TT",
      "risk_allele": "G",
      "chromosome": "15",
      "position": "75012985",
      "interpretation": "Homozygous TT genotype",
      "clinical_significance": "low",
      "notes": "Affects polycyclic aromatic hydrocarbon metabolism"
    },
    {
      "rsid": "rs4680",
      "gene": "COMT",
      "variant": "Val158Met",
      "category": "Mental/Cognitive",
      "affects": "Catechol metabolism, dopamine/norepinephrine breakdown",
      "user_genotype": "AG",
      "risk_allele": "A (Met allele)",
      "chromosome": "22",
      "position": "19951271",
      "interpretation": "Val/Met, intermediate metabolism",
      "clinical_significance": "moderate",
      "notes": "Warrior vs Worrier phenotype; also affects pain sensitivity"
    },
    {
      "rsid": "rs1815739",
      "gene": "ACTN3",
      "variant": "R577X",
      "category": "Fitness",
      "affects": "Fast-twitch muscle fiber composition",
      "user_genotype": "CT",
      "risk_allele": "X",
      "chromosome": "11",
      "position": "66328095",
      "interpretation": "R/X, intermediate phenotype",
      "clinical_significance": "moderate",
      "notes": "ACTN3 R allele associated with elite sprinters; X/X with elite endurance athletes"
    },
    {
      "rsid": "rs8192678",
      "gene": "PPARGC1A",
      "variant": "Gly482Ser",
      "category": "Fitness",
      "affects": "Aerobic capacity, mitochondrial biogenesis",
      "user_genotype": "CC",
      "risk_allele": "A",
      "chromosome": "4",
      "position": "23815662",
      "interpretation": "Gly/Gly, superior aerobic capacity and mitochondrial function",
      "clinical_significance": "moderate",
      "notes": "PGC-1alpha is master regulator of mitochondrial biogenesis"
    },
    {
      "rsid": "rs1800012",
      "gene": "COL1A1",
      "variant": "Sp1 promoter (Xbal)",
      "category": "Fitness",
      "affects": "Collagen synthesis, connective tissue strength",
      "user_genotype": "AC",
      "risk_allele": "S",
      "chromosome": "17",
      "position": "48277749",
      "interpretation": "Heterozygous genotype",
      "clinical_significance": "low",
      "notes": "Affects injury susceptibility in athletes"
    },
    {
      "rsid": "rs7136446",
      "gene": "COL5A1",
      "variant": "rs7136446",
      "category": "Fitness",
      "affects": "Collagen V synthesis, ligament/tendon properties",
      "user_genotype": "CT",
      "risk_allele": "C",
      "chromosome": "12",
      "position": "102838515",
      "interpretation": "Heterozygous genotype",
      "clinical_significance": "low",
      "notes": "Type V collagen affects soft tissue properties"
    },
    {
      "rsid": "rs1801260",
      "gene": "CLOCK",
      "variant": "A3111T",
      "category": "Sleep/Circadian",
      "affects": "Circadian rhythm, sleep timing",
      "user_genotype": "AA",
      "risk_allele": "T",
      "chromosome": "4",
      "position": "56301369",
      "interpretation": "Morning preference, earlier sleep/wake timing",
      "clinical_significance": "low",
      "notes": "CLOCK is master circadian regulator; affects chronotype"
    },
    {
      "rsid": "rs73598374",
      "gene": "ADA",
      "variant": "rs73598374",
      "category": "Sleep/Circadian",
      "affects": "Deep sleep efficiency",
      "user_genotype": "CC",
      "risk_allele": "A",
      "chromosome": "20",
      "position": "43280227",
      "interpretation": "Homozygous CC genotype",
      "clinical_significance": "low",
      "notes": "Adenosine deaminase affects adenosine-mediated sleep pressure"
    },
    {
      "rsid": "rs2802292",
      "gene": "FOXO3",
      "variant": "rs2802292",
      "category": "Longevity",
      "affects": "Longevity and healthy aging",
      "user_genotype": "GT",
      "risk_allele": "A",
      "chromosome": "6",
      "position": "108908518",
      "interpretation": "Heterozygous genotype",
      "clinical_significance": "moderate",
      "notes": "FOXO3 is major longevity gene; G allele associated with longer lifespan"
    },
    {
      "rsid": "rs1042522",
      "gene": "TP53",
      "variant": "Arg72Pro",
      "category": "Longevity",
      "affects": "Tumor suppression, cancer risk",
      "user_genotype": "CC",
      "risk_allele": "G",
      "chromosome": "17",
      "position": "7579472",
      "interpretation": "Pro/Pro, potentially more efficient tumor suppression",
      "clinical_significance": "moderate",
      "notes": "p53 is guardian of the genome; affects cancer risk"
    },
    {
      "rsid": "rs1800566",
      "gene": "NQO1",
      "variant": "C609T (Pro187Ser)",
      "category": "Longevity",
      "affects": "Antioxidant defense, NAD(P)H quinone oxidoreductase",
      "user_genotype": "GG",
      "risk_allele": "T",
      "chromosome": "16",
      "position": "69745145",
      "interpretation": "Homozygous GG genotype",
      "clinical_significance": "moderate",
      "notes": "Deficiency increases cancer risk from benzene and other quinones"
    },
    {
      "rsid": "rs4880",
      "gene": "SOD2",
      "variant": "Ala16Val (Val9Ala)",
      "category": "Longevity",
      "affects": "Mitochondrial antioxidant defense",
      "user_genotype": "AA",
      "risk_allele": "A (Val)",
      "chromosome": "6",
      "position": "160113872",
      "interpretation": "Val/Val, reduced mitochondrial superoxide dismutase activity",
      "clinical_significance": "moderate",
      "notes": "MnSOD is key mitochondrial antioxidant defense"
    },
    {
      "rsid": "rs6265",
      "gene": "BDNF",
      "variant": "Val66Met",
      "category": "Mental/Cognitive",
      "affects": "Brain-derived neurotrophic factor, neuroplasticity, learning",
      "user_genotype": "CC",
      "risk_allele": "A (Met)",
      "chromosome": "11",
      "position": "27679916",
      "interpretation": "Homozygous CC genotype",
      "clinical_significance": "moderate",
      "notes": "Met allele associated with anxiety-like traits and depression risk"
    },
    {
      "rsid": "rs53576",
      "gene": "OXTR",
      "variant": "rs53576",
      "category": "Mental/Cognitive",
      "affects": "Oxytocin receptor, social bonding, empathy",
      "user_genotype": "GG",
      "risk_allele": "A",
      "chromosome": "3",
      "position": "8804371",
      "interpretation": "Lower oxytocin receptor expression, less empathy/social sensitivity",
      "clinical_significance": "low",
      "notes": "Affects social bonding, parenting, and stress response"
    },
    {
      "rsid": "rs4570625",
      "gene": "TPH2",
      "variant": "G/A (-703)",
      "category": "Mental/Cognitive",
      "affects": "Tryptophan hydroxylase, serotonin synthesis",
      "user_genotype": "GG",
      "risk_allele": "A",
      "chromosome": "12",
      "position": "72331923",
      "interpretation": "Higher serotonin production",
      "clinical_significance": "low",
      "notes": "Polymorphism affects serotonin availability"
    },
    {
      "rsid": "rs6311",
      "gene": "HTR2A",
      "variant": "-1438G/A",
      "category": "Mental/Cognitive",
      "affects": "Serotonin 2A receptor, mood, aggression",
      "user_genotype": "TT",
      "risk_allele": "A",
      "chromosome": "13",
      "position": "47471478",
      "interpretation": "Homozygous TT genotype",
      "clinical_significance": "low",
      "notes": "Associated with depression, suicidality, and aggression"
    },
    {
      "rsid": "rs1800497",
      "gene": "DRD2/ANKK1",
      "variant": "Taq1A",
      "category": "Mental/Cognitive",
      "affects": "Dopamine receptor density, motivation, reward",
      "user_genotype": "GG",
      "risk_allele": "T (A1 allele)",
      "chromosome": "11",
      "position": "113270828",
      "interpretation": "Homozygous GG genotype",
      "clinical_significance": "moderate",
      "notes": "A1 allele associated with lower dopamine sensitivity and addiction"
    },
    {
      "rsid": "rs762551",
      "gene": "CYP1A2",
      "variant": "C163A (-163)",
      "category": "Drug Metabolism",
      "affects": "Caffeine metabolism speed",
      "user_genotype": "AA",
      "risk_allele": "A",
      "chromosome": "15",
      "position": "75041917",
      "interpretation": "Slow caffeine metabolizer, jitteriness/anxiety at normal doses",
      "clinical_significance": "low",
      "notes": "Explains individual caffeine sensitivity; affects 1-2 day half-life"
    },
    {
      "rsid": "rs1229984",
      "gene": "ADH1B",
      "variant": "Arg47His",
      "category": "Drug Metabolism",
      "affects": "Alcohol metabolism speed",
      "user_genotype": "CC",
      "risk_allele": "A",
      "chromosome": "4",
      "position": "100239319",
      "interpretation": "Homozygous CC genotype",
      "clinical_significance": "moderate",
      "notes": "Asian populations enriched for fast metabolism; protective against alcoholism"
    },
    {
      "rsid": "rs671",
      "gene": "ALDH2",
      "variant": "Glu504Lys",
      "category": "Drug Metabolism",
      "affects": "Aldehyde dehydrogenase, alcohol flush reaction",
      "user_genotype": "GG",
      "risk_allele": "A",
      "chromosome": "12",
      "position": "112241766",
      "interpretation": "Normal acetaldehyde metabolism",
      "clinical_significance": "moderate",
      "notes": "East Asian variant; 50% of populations in China, Japan, Korea have deficiency"
    },
    {
      "rsid": "rs4149056",
      "gene": "SLCO1B1",
      "variant": "T521C",
      "category": "Drug Metabolism",
      "affects": "Statin metabolism, drug interactions",
      "user_genotype": "TT",
      "risk_allele": "C",
      "chromosome": "12",
      "position": "21331549",
      "interpretation": "Normal statin metabolism",
      "clinical_significance": "moderate",
      "notes": "Important for statin dosing and side effect risk"
    },
    {
      "rsid": "rs2187668",
      "gene": "HLA-DQ2.5",
      "variant": "rs2187668",
      "category": "Immune",
      "affects": "Celiac disease susceptibility",
      "user_genotype": "TT",
      "risk_allele": "A",
      "chromosome": "6",
      "position": "32605884",
      "interpretation": "Homozygous TT genotype",
      "clinical_significance": "high",
      "notes": "95% of celiac disease patients carry HLA-DQ2 or HLA-DQ8"
    },
    {
      "rsid": "rs7454108",
      "gene": "HLA-DQ8",
      "variant": "rs7454108",
      "category": "Immune",
      "affects": "Celiac disease susceptibility",
      "user_genotype": "TT",
      "risk_allele": "T",
      "chromosome": "6",
      "position": "32681483",
      "interpretation": "DQ8 homozygous, increased celiac risk",
      "clinical_significance": "high",
      "notes": "Accounts for ~5% of celiac patients; complementary to DQ2"
    }
  ],
  "apoe_status": {
    "rs429358_genotype": "TT",
    "rs7412_genotype": "CC",
    "apoe_status": "\u03b53\u03b53",
    "alleles_detected": [
      "\u03b53",
      "\u03b53"
    ],
    "interpretation": "Common genotype, average AD risk, average cardiovascular risk"
  },
  "summary_by_category": {
    "Cardiovascular": [
      {
        "rsid": "rs1801133",
        "gene": "MTHFR",
        "variant": "C677T",
        "category": "Cardiovascular",
        "affects": "Folate metabolism, homocysteine levels",
        "user_genotype": "AG",
        "risk_allele": "T",
        "chromosome": "1",
        "position": "11856378",
        "interpretation": "Heterozygous genotype",
        "clinical_significance": "moderate",
        "notes": "Elevated homocysteine increases cardiovascular and thrombotic risk"
      },
      {
        "rsid": "rs1801131",
        "gene": "MTHFR",
        "variant": "A1298C",
        "category": "Cardiovascular",
        "affects": "Folate metabolism (secondary site)",
        "user_genotype": "TT",
        "risk_allele": "C",
        "chromosome": "1",
        "position": "11854476",
        "interpretation": "Homozygous TT genotype",
        "clinical_significance": "low",
        "notes": "Less severe than C677T variant"
      },
      {
        "rsid": "rs6025",
        "gene": "F5 (Factor V)",
        "variant": "Leiden (R506Q)",
        "category": "Cardiovascular",
        "affects": "Blood clotting resistance to anticoagulant protein C",
        "user_genotype": "CC",
        "risk_allele": "A",
        "chromosome": "1",
        "position": "169519049",
        "interpretation": "Homozygous CC genotype",
        "clinical_significance": "high",
        "notes": "Factor V Leiden - most common inherited thrombophilia in Europeans"
      },
      {
        "rsid": "rs429358",
        "gene": "APOE",
        "variant": "\u03b52/\u03b53/\u03b54 (Cys112Arg)",
        "category": "Cardiovascular",
        "affects": "Cholesterol metabolism, Alzheimer's disease risk",
        "user_genotype": "TT",
        "risk_allele": "C (\u03b54)",
        "chromosome": "19",
        "position": "45411941",
        "interpretation": "\u03b52/\u03b52 genotype (APOE2) - lowest Alzheimer's risk, lower LDL",
        "clinical_significance": "high",
        "notes": "Requires rs7412 to determine full APOE status"
      },
      {
        "rsid": "rs7412",
        "gene": "APOE",
        "variant": "\u03b52/\u03b53/\u03b54 (Arg158Cys)",
        "category": "Cardiovascular",
        "affects": "Cholesterol metabolism, Alzheimer's disease risk",
        "user_genotype": "CC",
        "risk_allele": "T (\u03b52)",
        "chromosome": "19",
        "position": "45412079",
        "interpretation": "\u03b53 or \u03b54 allele",
        "clinical_significance": "high",
        "notes": "Combined with rs429358 to determine APOE2/3/4 status"
      },
      {
        "rsid": "rs662",
        "gene": "PON1",
        "variant": "Q192R",
        "category": "Cardiovascular",
        "affects": "Oxidative stress protection, HDL function",
        "user_genotype": "CT",
        "risk_allele": "A",
        "chromosome": "7",
        "position": "94937446",
        "interpretation": "Heterozygous genotype",
        "clinical_significance": "low",
        "notes": "Affects HDL's ability to protect against LDL oxidation"
      },
      {
        "rsid": "rs5186",
        "gene": "AGTR1",
        "variant": "A1166C",
        "category": "Cardiovascular",
        "affects": "Blood pressure regulation",
        "user_genotype": "AC",
        "risk_allele": "C",
        "chromosome": "3",
        "position": "148459988",
        "interpretation": "Intermediate risk",
        "clinical_significance": "moderate",
        "notes": "Affects angiotensin II signaling in blood vessels"
      },
      {
        "rsid": "rs1800796",
        "gene": "IL6",
        "variant": "-174G/C",
        "category": "Cardiovascular",
        "affects": "Inflammation, IL-6 levels",
        "user_genotype": "GG",
        "risk_allele": "C",
        "chromosome": "7",
        "position": "22766246",
        "interpretation": "Higher IL-6 production, pro-inflammatory",
        "clinical_significance": "low",
        "notes": "IL-6 is a key inflammatory cytokine"
      },
      {
        "rsid": "rs1800795",
        "gene": "IL6",
        "variant": "-174G>C",
        "category": "Cardiovascular",
        "affects": "IL-6 levels and inflammation",
        "user_genotype": "GG",
        "risk_allele": "G",
        "chromosome": "7",
        "position": "22766645",
        "interpretation": "Increased IL-6 levels",
        "clinical_significance": "low",
        "notes": "May be same as rs1800796"
      },
      {
        "rsid": "rs1800629",
        "gene": "TNF",
        "variant": "-308G/A",
        "category": "Cardiovascular",
        "affects": "TNF-alpha inflammation marker",
        "user_genotype": "AG",
        "risk_allele": "A",
        "chromosome": "6",
        "position": "31543031",
        "interpretation": "Intermediate TNF-alpha levels",
        "clinical_significance": "low",
        "notes": "TNF-alpha is a major inflammatory cytokine"
      },
      {
        "rsid": "rs3798220",
        "gene": "LPA",
        "variant": "IVS25+323C/G",
        "category": "Cardiovascular",
        "affects": "Lipoprotein(a) levels, cardiovascular risk",
        "user_genotype": "TT",
        "risk_allele": "G",
        "chromosome": "6",
        "position": "160961137",
        "interpretation": "Homozygous TT genotype",
        "clinical_significance": "moderate",
        "notes": "Elevated Lp(a) is independent cardiovascular risk factor"
      },
      {
        "rsid": "rs10455872",
        "gene": "LPA",
        "variant": "Pentanucleotide repeat",
        "category": "Cardiovascular",
        "affects": "Lipoprotein(a) levels, cardiovascular risk",
        "user_genotype": "AA",
        "risk_allele": "T",
        "chromosome": "6",
        "position": "161010118",
        "interpretation": "Homozygous AA genotype",
        "clinical_significance": "moderate",
        "notes": "Works with rs3798220 to determine Lp(a) phenotype"
      }
    ],
    "Metabolic": [
      {
        "rsid": "rs1801282",
        "gene": "PPARG",
        "variant": "Pro12Ala",
        "category": "Metabolic",
        "affects": "Insulin sensitivity, metabolic syndrome risk",
        "user_genotype": "CC",
        "risk_allele": "G",
        "chromosome": "3",
        "position": "12393125",
        "interpretation": "Normal insulin sensitivity",
        "clinical_significance": "moderate",
        "notes": "Ala allele is protective, reduces diabetes risk by ~25%"
      },
      {
        "rsid": "rs7903146",
        "gene": "TCF7L2",
        "variant": "rs7903146",
        "category": "Metabolic",
        "affects": "Type 2 diabetes risk (strongest known locus)",
        "user_genotype": "CT",
        "risk_allele": "T",
        "chromosome": "10",
        "position": "114758349",
        "interpretation": "~1.4x increased diabetes risk",
        "clinical_significance": "high",
        "notes": "Most significant T2D susceptibility gene; each T allele ~20% increased risk"
      },
      {
        "rsid": "rs5219",
        "gene": "KCNJ11",
        "variant": "E23K",
        "category": "Metabolic",
        "affects": "Insulin secretion and glucose control",
        "user_genotype": "CC",
        "risk_allele": "A",
        "chromosome": "11",
        "position": "17409572",
        "interpretation": "K allele, normal insulin secretion",
        "clinical_significance": "moderate",
        "notes": "Affects ATP-sensitive potassium channel in pancreatic beta cells"
      },
      {
        "rsid": "rs13266634",
        "gene": "SLC30A8",
        "variant": "R325W",
        "category": "Metabolic",
        "affects": "Zinc transporter, insulin secretion",
        "user_genotype": "CT",
        "risk_allele": "A",
        "chromosome": "8",
        "position": "118184783",
        "interpretation": "Heterozygous genotype",
        "clinical_significance": "moderate",
        "notes": "Zinc transport critical for insulin secretion"
      },
      {
        "rsid": "rs4402960",
        "gene": "IGF2BP2",
        "variant": "rs4402960",
        "category": "Metabolic",
        "affects": "Type 2 diabetes risk",
        "user_genotype": "GT",
        "risk_allele": "T",
        "chromosome": "3",
        "position": "185511687",
        "interpretation": "Heterozygous genotype",
        "clinical_significance": "low",
        "notes": "Involved in glucose metabolism"
      },
      {
        "rsid": "rs10811661",
        "gene": "CDKN2A/B",
        "variant": "rs10811661",
        "category": "Metabolic",
        "affects": "Type 2 diabetes and pancreatic cancer risk",
        "user_genotype": "CT",
        "risk_allele": "A",
        "chromosome": "9",
        "position": "22134094",
        "interpretation": "Heterozygous genotype",
        "clinical_significance": "moderate",
        "notes": "Cell cycle regulator"
      },
      {
        "rsid": "rs9939609",
        "gene": "FTO",
        "variant": "A/T",
        "category": "Metabolic",
        "affects": "Obesity risk, appetite regulation",
        "user_genotype": "AT",
        "risk_allele": "A",
        "chromosome": "16",
        "position": "53820527",
        "interpretation": "Intermediate obesity risk (~1.3x)",
        "clinical_significance": "moderate",
        "notes": "Most significant obesity-associated SNP; affects appetite circuits"
      },
      {
        "rsid": "rs17782313",
        "gene": "MC4R",
        "variant": "rs17782313",
        "category": "Metabolic",
        "affects": "Obesity risk, appetite/satiety",
        "user_genotype": "TT",
        "risk_allele": "C",
        "chromosome": "18",
        "position": "57851097",
        "interpretation": "Homozygous TT genotype",
        "clinical_significance": "moderate",
        "notes": "Melanocortin-4 receptor crucial for appetite control"
      },
      {
        "rsid": "rs1042713",
        "gene": "ADRB2",
        "variant": "Arg16Gly",
        "category": "Metabolic",
        "affects": "Beta-2 adrenergic receptor, metabolic rate",
        "user_genotype": "AA",
        "risk_allele": "C",
        "chromosome": "5",
        "position": "148206440",
        "interpretation": "Arg/Arg, higher metabolic rate and norepinephrine sensitivity",
        "clinical_significance": "low",
        "notes": "Affects sympathetic nervous system response"
      },
      {
        "rsid": "rs1042714",
        "gene": "ADRB2",
        "variant": "Gln27Glu",
        "category": "Metabolic",
        "affects": "Beta-2 adrenergic receptor, weight regulation",
        "user_genotype": "CC",
        "risk_allele": "G",
        "chromosome": "5",
        "position": "148206473",
        "interpretation": "Homozygous CC genotype",
        "clinical_significance": "low",
        "notes": "Works with rs1042713 for metabolic effects"
      },
      {
        "rsid": "rs4994",
        "gene": "ADRB3",
        "variant": "Trp64Arg",
        "category": "Metabolic",
        "affects": "Beta-3 adrenergic receptor, metabolic efficiency",
        "user_genotype": "AA",
        "risk_allele": "C",
        "chromosome": "8",
        "position": "37823798",
        "interpretation": "Homozygous AA genotype",
        "clinical_significance": "low",
        "notes": "Involved in thermogenesis and fat mobilization"
      }
    ],
    "Nutrient Metabolism": [
      {
        "rsid": "rs4988235",
        "gene": "MCM6/LCT",
        "variant": "C/T (-13910)",
        "category": "Nutrient Metabolism",
        "affects": "Lactose tolerance",
        "user_genotype": "GG",
        "risk_allele": "A (old nomenclature)",
        "chromosome": "2",
        "position": "136608646",
        "interpretation": "Homozygous GG genotype",
        "clinical_significance": "moderate",
        "notes": "Determines adult lactase persistence; common in Northern European ancestry"
      },
      {
        "rsid": "rs1801394",
        "gene": "MTRR",
        "variant": "A66G",
        "category": "Nutrient Metabolism",
        "affects": "B12 metabolism, methionine cycle",
        "user_genotype": "AG",
        "risk_allele": "A",
        "chromosome": "5",
        "position": "7870973",
        "interpretation": "Intermediate enzyme activity",
        "clinical_significance": "low",
        "notes": "Related to homocysteine metabolism"
      },
      {
        "rsid": "rs1805087",
        "gene": "MTR",
        "variant": "A2756G",
        "category": "Nutrient Metabolism",
        "affects": "B12 and methionine metabolism",
        "user_genotype": "AA",
        "risk_allele": "A",
        "chromosome": "1",
        "position": "237048500",
        "interpretation": "Potential B12/methionine metabolism issues",
        "clinical_significance": "low",
        "notes": "Cofactor required for methylation reactions"
      },
      {
        "rsid": "rs602662",
        "gene": "FUT2",
        "variant": "A/G",
        "category": "Nutrient Metabolism",
        "affects": "B12 absorption, gut microbiota",
        "user_genotype": "AA",
        "risk_allele": "A",
        "chromosome": "19",
        "position": "49206985",
        "interpretation": "Non-secretor, reduced B12 absorption from food",
        "clinical_significance": "low",
        "notes": "FUT2 secretor status affects B12 and micronutrient availability"
      },
      {
        "rsid": "rs7041",
        "gene": "GC/VDBP",
        "variant": "D432E",
        "category": "Nutrient Metabolism",
        "affects": "Vitamin D binding protein, vitamin D status",
        "user_genotype": "CC",
        "risk_allele": "A",
        "chromosome": "4",
        "position": "72618334",
        "interpretation": "Homozygous CC genotype",
        "clinical_significance": "moderate",
        "notes": "Affects vitamin D distribution and bioavailability"
      },
      {
        "rsid": "rs4588",
        "gene": "GC/VDBP",
        "variant": "T436K",
        "category": "Nutrient Metabolism",
        "affects": "Vitamin D binding protein",
        "user_genotype": "GG",
        "risk_allele": "T",
        "chromosome": "4",
        "position": "72618323",
        "interpretation": "Isoform 1f or 2",
        "clinical_significance": "moderate",
        "notes": "Works with rs7041 to determine VDBP isoform"
      },
      {
        "rsid": "rs1800562",
        "gene": "HFE",
        "variant": "C282Y",
        "category": "Nutrient Metabolism",
        "affects": "Iron overload risk (hemochromatosis)",
        "user_genotype": "GG",
        "risk_allele": "A",
        "chromosome": "6",
        "position": "26093141",
        "interpretation": "Homozygous GG genotype",
        "clinical_significance": "high",
        "notes": "Most common genetic cause of hemochromatosis"
      },
      {
        "rsid": "rs1799945",
        "gene": "HFE",
        "variant": "H63D",
        "category": "Nutrient Metabolism",
        "affects": "Iron overload risk (secondary)",
        "user_genotype": "CG",
        "risk_allele": "G",
        "chromosome": "6",
        "position": "26091179",
        "interpretation": "Heterozygous carrier",
        "clinical_significance": "low",
        "notes": "Secondary hemochromatosis mutation; rarely causes disease alone"
      },
      {
        "rsid": "rs855791",
        "gene": "TMPRSS6",
        "variant": "A736V",
        "category": "Nutrient Metabolism",
        "affects": "Iron levels and hepcidin regulation",
        "user_genotype": "GG",
        "risk_allele": "T",
        "chromosome": "22",
        "position": "37462936",
        "interpretation": "Homozygous GG genotype",
        "clinical_significance": "low",
        "notes": "Regulates iron absorption through hepcidin"
      },
      {
        "rsid": "rs234706",
        "gene": "CBS",
        "variant": "C699T",
        "category": "Nutrient Metabolism",
        "affects": "Homocysteine and sulfur metabolism",
        "user_genotype": "AG",
        "risk_allele": "T",
        "chromosome": "21",
        "position": "44485350",
        "interpretation": "Heterozygous genotype",
        "clinical_significance": "low",
        "notes": "CBS is gateway to sulfur metabolism"
      },
      {
        "rsid": "rs1695",
        "gene": "GSTP1",
        "variant": "A313G (Ile105Val)",
        "category": "Nutrient Metabolism",
        "affects": "Detoxification, glutathione S-transferase activity",
        "user_genotype": "AA",
        "risk_allele": "G",
        "chromosome": "11",
        "position": "67352689",
        "interpretation": "Normal detox capacity",
        "clinical_significance": "low",
        "notes": "Phase II detox enzyme for environmental toxins"
      },
      {
        "rsid": "rs1048943",
        "gene": "CYP1A1",
        "variant": "A2455G",
        "category": "Nutrient Metabolism",
        "affects": "Phase I detoxification (CYP1A1 induction)",
        "user_genotype": "TT",
        "risk_allele": "G",
        "chromosome": "15",
        "position": "75012985",
        "interpretation": "Homozygous TT genotype",
        "clinical_significance": "low",
        "notes": "Affects polycyclic aromatic hydrocarbon metabolism"
      }
    ],
    "Mental/Cognitive": [
      {
        "rsid": "rs4680",
        "gene": "COMT",
        "variant": "Val158Met",
        "category": "Mental/Cognitive",
        "affects": "Catechol metabolism, dopamine/norepinephrine breakdown",
        "user_genotype": "AG",
        "risk_allele": "A (Met allele)",
        "chromosome": "22",
        "position": "19951271",
        "interpretation": "Val/Met, intermediate metabolism",
        "clinical_significance": "moderate",
        "notes": "Warrior vs Worrier phenotype; also affects pain sensitivity"
      },
      {
        "rsid": "rs6265",
        "gene": "BDNF",
        "variant": "Val66Met",
        "category": "Mental/Cognitive",
        "affects": "Brain-derived neurotrophic factor, neuroplasticity, learning",
        "user_genotype": "CC",
        "risk_allele": "A (Met)",
        "chromosome": "11",
        "position": "27679916",
        "interpretation": "Homozygous CC genotype",
        "clinical_significance": "moderate",
        "notes": "Met allele associated with anxiety-like traits and depression risk"
      },
      {
        "rsid": "rs53576",
        "gene": "OXTR",
        "variant": "rs53576",
        "category": "Mental/Cognitive",
        "affects": "Oxytocin receptor, social bonding, empathy",
        "user_genotype": "GG",
        "risk_allele": "A",
        "chromosome": "3",
        "position": "8804371",
        "interpretation": "Lower oxytocin receptor expression, less empathy/social sensitivity",
        "clinical_significance": "low",
        "notes": "Affects social bonding, parenting, and stress response"
      },
      {
        "rsid": "rs4570625",
        "gene": "TPH2",
        "variant": "G/A (-703)",
        "category": "Mental/Cognitive",
        "affects": "Tryptophan hydroxylase, serotonin synthesis",
        "user_genotype": "GG",
        "risk_allele": "A",
        "chromosome": "12",
        "position": "72331923",
        "interpretation": "Higher serotonin production",
        "clinical_significance": "low",
        "notes": "Polymorphism affects serotonin availability"
      },
      {
        "rsid": "rs6311",
        "gene": "HTR2A",
        "variant": "-1438G/A",
        "category": "Mental/Cognitive",
        "affects": "Serotonin 2A receptor, mood, aggression",
        "user_genotype": "TT",
        "risk_allele": "A",
        "chromosome": "13",
        "position": "47471478",
        "interpretation": "Homozygous TT genotype",
        "clinical_significance": "low",
        "notes": "Associated with depression, suicidality, and aggression"
      },
      {
        "rsid": "rs1800497",
        "gene": "DRD2/ANKK1",
        "variant": "Taq1A",
        "category": "Mental/Cognitive",
        "affects": "Dopamine receptor density, motivation, reward",
        "user_genotype": "GG",
        "risk_allele": "T (A1 allele)",
        "chromosome": "11",
        "position": "113270828",
        "interpretation": "Homozygous GG genotype",
        "clinical_significance": "moderate",
        "notes": "A1 allele associated with lower dopamine sensitivity and addiction"
      }
    ],
    "Fitness": [
      {
        "rsid": "rs1815739",
        "gene": "ACTN3",
        "variant": "R577X",
        "category": "Fitness",
        "affects": "Fast-twitch muscle fiber composition",
        "user_genotype": "CT",
        "risk_allele": "X",
        "chromosome": "11",
        "position": "66328095",
        "interpretation": "R/X, intermediate phenotype",
        "clinical_significance": "moderate",
        "notes": "ACTN3 R allele associated with elite sprinters; X/X with elite endurance athletes"
      },
      {
        "rsid": "rs8192678",
        "gene": "PPARGC1A",
        "variant": "Gly482Ser",
        "category": "Fitness",
        "affects": "Aerobic capacity, mitochondrial biogenesis",
        "user_genotype": "CC",
        "risk_allele": "A",
        "chromosome": "4",
        "position": "23815662",
        "interpretation": "Gly/Gly, superior aerobic capacity and mitochondrial function",
        "clinical_significance": "moderate",
        "notes": "PGC-1alpha is master regulator of mitochondrial biogenesis"
      },
      {
        "rsid": "rs1800012",
        "gene": "COL1A1",
        "variant": "Sp1 promoter (Xbal)",
        "category": "Fitness",
        "affects": "Collagen synthesis, connective tissue strength",
        "user_genotype": "AC",
        "risk_allele": "S",
        "chromosome": "17",
        "position": "48277749",
        "interpretation": "Heterozygous genotype",
        "clinical_significance": "low",
        "notes": "Affects injury susceptibility in athletes"
      },
      {
        "rsid": "rs7136446",
        "gene": "COL5A1",
        "variant": "rs7136446",
        "category": "Fitness",
        "affects": "Collagen V synthesis, ligament/tendon properties",
        "user_genotype": "CT",
        "risk_allele": "C",
        "chromosome": "12",
        "position": "102838515",
        "interpretation": "Heterozygous genotype",
        "clinical_significance": "low",
        "notes": "Type V collagen affects soft tissue properties"
      }
    ],
    "Sleep/Circadian": [
      {
        "rsid": "rs1801260",
        "gene": "CLOCK",
        "variant": "A3111T",
        "category": "Sleep/Circadian",
        "affects": "Circadian rhythm, sleep timing",
        "user_genotype": "AA",
        "risk_allele": "T",
        "chromosome": "4",
        "position": "56301369",
        "interpretation": "Morning preference, earlier sleep/wake timing",
        "clinical_significance": "low",
        "notes": "CLOCK is master circadian regulator; affects chronotype"
      },
      {
        "rsid": "rs73598374",
        "gene": "ADA",
        "variant": "rs73598374",
        "category": "Sleep/Circadian",
        "affects": "Deep sleep efficiency",
        "user_genotype": "CC",
        "risk_allele": "A",
        "chromosome": "20",
        "position": "43280227",
        "interpretation": "Homozygous CC genotype",
        "clinical_significance": "low",
        "notes": "Adenosine deaminase affects adenosine-mediated sleep pressure"
      }
    ],
    "Longevity": [
      {
        "rsid": "rs2802292",
        "gene": "FOXO3",
        "variant": "rs2802292",
        "category": "Longevity",
        "affects": "Longevity and healthy aging",
        "user_genotype": "GT",
        "risk_allele": "A",
        "chromosome": "6",
        "position": "108908518",
        "interpretation": "Heterozygous genotype",
        "clinical_significance": "moderate",
        "notes": "FOXO3 is major longevity gene; G allele associated with longer lifespan"
      },
      {
        "rsid": "rs1042522",
        "gene": "TP53",
        "variant": "Arg72Pro",
        "category": "Longevity",
        "affects": "Tumor suppression, cancer risk",
        "user_genotype": "CC",
        "risk_allele": "G",
        "chromosome": "17",
        "position": "7579472",
        "interpretation": "Pro/Pro, potentially more efficient tumor suppression",
        "clinical_significance": "moderate",
        "notes": "p53 is guardian of the genome; affects cancer risk"
      },
      {
        "rsid": "rs1800566",
        "gene": "NQO1",
        "variant": "C609T (Pro187Ser)",
        "category": "Longevity",
        "affects": "Antioxidant defense, NAD(P)H quinone oxidoreductase",
        "user_genotype": "GG",
        "risk_allele": "T",
        "chromosome": "16",
        "position": "69745145",
        "interpretation": "Homozygous GG genotype",
        "clinical_significance": "moderate",
        "notes": "Deficiency increases cancer risk from benzene and other quinones"
      },
      {
        "rsid": "rs4880",
        "gene": "SOD2",
        "variant": "Ala16Val (Val9Ala)",
        "category": "Longevity",
        "affects": "Mitochondrial antioxidant defense",
        "user_genotype": "AA",
        "risk_allele": "A (Val)",
        "chromosome": "6",
        "position": "160113872",
        "interpretation": "Val/Val, reduced mitochondrial superoxide dismutase activity",
        "clinical_significance": "moderate",
        "notes": "MnSOD is key mitochondrial antioxidant defense"
      }
    ],
    "Drug Metabolism": [
      {
        "rsid": "rs762551",
        "gene": "CYP1A2",
        "variant": "C163A (-163)",
        "category": "Drug Metabolism",
        "affects": "Caffeine metabolism speed",
        "user_genotype": "AA",
        "risk_allele": "A",
        "chromosome": "15",
        "position": "75041917",
        "interpretation": "Slow caffeine metabolizer, jitteriness/anxiety at normal doses",
        "clinical_significance": "low",
        "notes": "Explains individual caffeine sensitivity; affects 1-2 day half-life"
      },
      {
        "rsid": "rs1229984",
        "gene": "ADH1B",
        "variant": "Arg47His",
        "category": "Drug Metabolism",
        "affects": "Alcohol metabolism speed",
        "user_genotype": "CC",
        "risk_allele": "A",
        "chromosome": "4",
        "position": "100239319",
        "interpretation": "Homozygous CC genotype",
        "clinical_significance": "moderate",
        "notes": "Asian populations enriched for fast metabolism; protective against alcoholism"
      },
      {
        "rsid": "rs671",
        "gene": "ALDH2",
        "variant": "Glu504Lys",
        "category": "Drug Metabolism",
        "affects": "Aldehyde dehydrogenase, alcohol flush reaction",
        "user_genotype": "GG",
        "risk_allele": "A",
        "chromosome": "12",
        "position": "112241766",
        "interpretation": "Normal acetaldehyde metabolism",
        "clinical_significance": "moderate",
        "notes": "East Asian variant; 50% of populations in China, Japan, Korea have deficiency"
      },
      {
        "rsid": "rs4149056",
        "gene": "SLCO1B1",
        "variant": "T521C",
        "category": "Drug Metabolism",
        "affects": "Statin metabolism, drug interactions",
        "user_genotype": "TT",
        "risk_allele": "C",
        "chromosome": "12",
        "position": "21331549",
        "interpretation": "Normal statin metabolism",
        "clinical_significance": "moderate",
        "notes": "Important for statin dosing and side effect risk"
      }
    ],
    "Immune": [
      {
        "rsid": "rs2187668",
        "gene": "HLA-DQ2.5",
        "variant": "rs2187668",
        "category": "Immune",
        "affects": "Celiac disease susceptibility",
        "user_genotype": "TT",
        "risk_allele": "A",
        "chromosome": "6",
        "position": "32605884",
        "interpretation": "Homozygous TT genotype",
        "clinical_significance": "high",
        "notes": "95% of celiac disease patients carry HLA-DQ2 or HLA-DQ8"
      },
      {
        "rsid": "rs7454108",
        "gene": "HLA-DQ8",
        "variant": "rs7454108",
        "category": "Immune",
        "affects": "Celiac disease susceptibility",
        "user_genotype": "TT",
        "risk_allele": "T",
        "chromosome": "6",
        "position": "32681483",
        "interpretation": "DQ8 homozygous, increased celiac risk",
        "clinical_significance": "high",
        "notes": "Accounts for ~5% of celiac patients; complementary to DQ2"
      }
    ]
  }
}